The term “precancerous” refers to a specific condition or group of abnormal-appearing cells that have a greater risk of becoming cancer if left untreated. Researchers have recently identified molecular or cellular changes that can help pinpoint early damage to healthy tissue before it becomes cancer. Therefore, understanding the changes that occur at the cellular and molecular level is an important way to prevent the appearance of some cancers. This book aims to become a comprehensive exploration of the highly intricate relationship between the presence of various pre-cancerous conditions, such as atypical cells, hyperplasia, dysplasia, chronic inflammation, and carcinoma in situ, along with the role of benign lesions in cancer development of different tissues. Therefore, contributions based on precancerous screening, development of new biomarkers, and improvement in tests and examinations to detect and monitor the progress of these different injuries, at the molecular and cellular levels, are welcome. Moreover, the book will explore the role of non-coding RNAs, including miRNAs and long non-coding RNAs, in the different pre-cancerous conditions. By amalgamating cutting-edge research and clinical insights, this book will serve as an indispensable guide for researchers, clinicians, and healthcare professionals passionate about advancing the detection and treatment of precancerous conditions.