Dr. Shivani Gandhi

By Shivani Gandhi, Ishani Gupta, Reetika Menia and Raman Kumar

Lung cancers, due to delays in diagnosis and availability of limited treatment resources, have become the leading cause of cancer-related death globally. With the recent advances in the identification of molecular mechanisms and profile of lung cancer, the understanding of novel characteristics of the molecular pathology of lung cancers as well as knowledge of driver mutations has been enhanced that has led to the development and success of targeted strategies against lung cancer. Diagnosis and treatment of this heterogeneous group of cancer have been revolutionized with the advent of the identification of genetic alterations. This chapter will summarize the etiopathogenesis, current knowledge depicting the series of events associated with the development of lung cancer, the molecular mechanism of most common and relevant genetic alterations in lung cancer along with a brief about the use of targeted therapies in lung cancer patients.

Part of the book: Molecular Histopathology and Cytopathology

By Shivani Gandhi, Reetika Menia, Ishani Gupta and Surbhi Mahajan

Histopathological examination is one of the important ancillary investigations to be done in medicolegal autopsies, particularly in sudden and natural deaths. Some of the liver diseases are silent that can contribute to fatal events in the later stages. Liver is one of the common viscera received in the pathology laboratory for histopathological examination. The findings in the liver vary from nonspecific to specific, which may or may not contribute to the cause of death. The important prerequisite for the histopathological examination is preservation. A well-preserved specimen gives detailed morphological details when compared to the poorly preserved specimen.

Part of the book: Unlocking the Mysteries of Death