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Daniela Lazar

Victor Babeș University of Medicine and Pharmacy Timișoara

Assoc. Prof. Dr. Daniela Lazar began her career in a center of excellence, the Department of Gastroenterology and Hepatology, University of Medicine and Pharmacy “Victor Babes” Timisoara, Romania, where she acquired clinical skills in gastroenterology, learned the techniques of endoscopy and abdominal ultrasonography and began her research activity. Besides gastroenterology, she showed interest in oncology and the research of gastrointestinal neoplastic conditions, especially gastric cancer. Dr. Lazar is specialized in gastroenterology, medical oncology, and internal medicine. Currently, besides academic and teaching activities, she conducts integrated clinical practice in the Department of Internal Medicine, Emergency Military Clinical Hospital Timisoara. Dr. Lazar obtained a PhD with a thesis on gastric cancer. She has participated in many national and international congresses with research studies in gastroenterology, internal medicine, and digestive oncology. She has published many papers on angiogenesis, premalignant lesions, and prognostic factors in gastric cancer in renowned international journals. She has also published review articles on targeted treatments and immunotherapy in gastric cancer, as well as the impact of artificial intelligence in diagnosing premalignant/malignant esophageal and gastric conditions. She is also interested in the epidemiology, phenotypes, and treatment of inflammatory bowel diseases, being part of the national and international working groups in this domain. Dr. Lazar is the author/co-author of several books and book chapters on different gastroenterological, oncological, and internal medicine topics. Moreover, Dr. Lazar is an academic book editor and a journal reviewer.

1books edited

4chapters authored

Latest work with IntechOpen by Daniela Lazar

Gastric cancer is the second most common cause of cancer-related death in the world. There are no screening tests available for its diagnosis, therefore patients usually presents in late stages, associated with poor prognosis. Currently, many efforts are made toward new advances in the treatment strategies. The book makes an insight into the assessment of premalignant lesions, current management of early gastric cancer, risk and protective factors in gastric carcinogenesis. "Gastric cancer" provides a detailed description of the morphologic classification, molecular changes and epigenetic alterations of this tumor. The book describes the role of different diagnostic tools in the preoperative assessment of patients and the most important factors contributing to the prognosis. Moreover, it describes the current surgical and chemotherapeutic options for gastric neoplasm. This publication may open new and interesting gates for further research concerning carcinogenesis, genetic and epigenetic alterations, signaling pathways, H. pylori infection, the discovery of protective factors against gastric cancer and of revolutionary therapies of this tumor.

Gastric Carcinoma

Gastric Carcinoma

Edited by Daniela Lazar

Chapters authored

Immunohistochemical Profile of Mucins in Gastric Carcinoma

By Daniela Lazar and Sorina Taban

Part of the book: Gastric Carcinoma

The Role of Endoscopy and Biopsy in Evaluating Preneoplastic and Particular Gastric Lesions

By Daniela Lazăr, Sorina Tăban and Sorin Ursoniu

Part of the book: Gastric Carcinoma

Molecular Prognostic Factors in Gastric Cancer

By Daniela Lazar, Sorina Taban, Marioara Cornianu, Alexandra Faur, Ioan Romosan and Adrian Goldis

Gastric cancer represents a major health problem worldwide. Literature data have demonstrated that gastric tumors present a high molecular heterogeneity, responsible for the process of carcinogenesis and dissemination. By revealing the molecular subtype of the tumor, it is possible to assess its behavior, the outcome of the patient, and the treatment approach, according to its genetic and epigenetic profile. This chapter aims to highlight some of the many different genetic mutations, epigenetic alterations, as well as aberrant signaling pathways involved in the pathogenesis of stomach cancers, each of these molecular abnormalities acting in a specific stage of the disease. Moreover, the manuscript describes the novel therapeutic agents that target some of these aberrant molecular signaling pathways. Unfortunately, only a few agents are currently part of the standard treatment of gastric cancer, while most of the others remain to prove their therapeutic efficacy in the setting of clinical trials. By discovering the different molecular subtypes of gastric cancer, as well as numerous classes of targeted molecular agents, in the future, we would be able to perform an individualized treatment, associated with maximum efficiency and less costs.

Part of the book: Gastric Cancer

Efficiency of Treatment Targeted on Gut Microbiota in Inflammatory Bowel Diseases: Current Strategies and Perspectives

By Daniela Cornelia Lazar, Elena-Alina Moacă, Mărioara Cornianu, Sorina Tăban, Alexandra Faur and Adrian Goldiș

Inflammatory bowel diseases (IBDs) represent a category of diseases characterized by intestinal inflammation and include two main entities, ulcerative colitis and Crohn’s disease, one of the representative clinical characteristics of which being chronic diarrhea. The etiology of these diseases is multifactorial, combining genetic, immunological, and also environmental factors, along with gut dysbiosis. In recent years, we encountered a higher incidence of IBD cases and of severe forms of disease. Therefore, there is an urgent need to develop new and efficient treatments, including strategies to improve the microbiome. In this chapter, we will discuss the current knowledge about the impact of different therapies influencing gut microbiota, such as prebiotics, probiotics, synbiotics, and other agents in IBD prevention, and also in the induction/maintenance of IBD remission. The manuscript will focus also on potential areas for research in the future using agents that modify intestinal microbiota and combined strategies.

Part of the book: Benign Anorectal Disorders

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