Chapters authored
Experimental and Computational Models of Atrial Fibrillation
Atrial fibrillation (AF) is the most common cardiac arrhythmia with potentially severe consequences that include stroke and sudden death. A high prevalence in the general population, combined with severe morbidity and mortality, make AF a major public health concern. Factors that predispose to AF are numerous and complex and include electrical, structural, neurohumoral, immunological and inflammatory remodeling of the heart. This chapter provides a review of animal and computational models of AF that have provided insights into this complex arrhythmia. These models bridge the gap between nonclinical and clinical research, and have been indispensable for expanding our understanding of the many factors that contribute to progression of this arrhythmia. Using a wide variety of investigational approaches and scientific models, researchers gain insights into mechanisms that affect the onset and progression of AF, as well as test novel treatments and therapeutic strategies.
Part of the book: From Supraventricular Tachycardias to Cardiac Resynchronization Therapy [Working title]