Chapters authored
The Role of Pseudomonas aeruginosa DsbA-1 in Bacterial Pathogenesis: Current Research and Future Prospects
Disulfide bond isomerase proteins (Dsbs) have been extensively characterized in gram-negative bacteria. Recently research efforts is being placed on their biology in gram-positive species. Modern “omics” technologies, allowed assessment of the contribution of the Dsbs to bacterial pathogenesis. The author cloned and characterized the dsbA 1 protein from Pseudomonas aeruginosa in the late 1990s. The global proteome analysis demonstrated that the dsbA gene is under the direct regulatory control of the extracytoplasmic function (ECF) sigma factor AlgT(U) or sigma-22. This is unique to P. aeruginosa. Disruption of dsbA gene results in pleiotropic phenotype: defect in assembly of cysteine disulfide bond containing proteins-as shown in many others. Recently, omics-based approaches identified expression changes in dsbA gene under different physiological states of bacterial pathogens-primarily in free-living, biofilm state, or under infectious disease conditions. Involvement of dsbA function in biofilm formation was shown using dsbA gene disruption mutants. This chapter documents past and current findings and concludes with future trends in research on Dsbs including peptidomimetics.
Part of the book: Pseudomonas aeruginosa
Anatomy and Physiology of the Uveal Tract: Maintaining the Eye’s Internal Balance
The uveal tract, comprising the iris, ciliary body, and choroid, is pivotal in maintaining the eye’s internal balance. The iris, with its pigmentation, regulates light entry through pupil control and contributes to eye color variation. The ciliary body, positioned behind the iris, facilitates accommodation by adjusting the lens for focusing at various distances and produces aqueous humor, crucial for intraocular pressure maintenance. The choroid, a vascular layer at the back of the eye, nourishes the retina. Together, these components uphold eye shape, control light entry, and support retinal function. Understanding uveal anatomy and physiology is fundamental to comprehending ocular mechanisms, encompassing both structural integrity and functional dynamics. This book chapter provides a knowledge of uveal anatomy and physiology.
Part of the book: Uveitis