Chapters authored
Artificial Intelligence Approaches to Chronic Kidney Disease-Mineral Bone Disorder
Chronic Kidney Disease: Mineral Bone Disorder (CKD-MBD) is a complex syndrome, encompassing biochemical, skeletal, and cardiovascular complications. The heterogeneity of individual manifestations, the multitude of contributory factors, and the absence of biomarkers to identify the complications and intervene early in the course have resulted in the current clinical approach, where clinicians are addressing primarily biochemical abnormalities in the advanced stages of chronic kidney disease. The late intervention and the use of surrogate targets that are far removed from the relevant clinical outcomes of fracture and accelerated cardiovascular disease, causes the poor survival of individuals with CKD. The identification of early events in the development of CKD-MBD and the recognition of novel mediators of CKD-associated skeletal and cardiovascular disease are setting the stage for a revolution in how we approach and treat CKD-MBD. The complexity of CKD-MBD lends itself to an alternative approach to management using an artificial intelligence approach combined with a sophisticated mathematical model of the disease to help clinicians target disease complications in a personalized fashion.
Part of the book: Chronic Kidney Disease