Carlos Garcia-Becerra
https://orcid.org/0000-0003-2838-6251
Chapters authored
High Intensity Focused Ultrasound (HIFU) in Prostate Diseases (Benign Prostatic Hyperplasia (BPH) and Prostate Cancer)
The minimally invasive, image-guided therapies are a clear option in the urologists’ armamentarium to treat BPH and prostate cancer. During the last decade, advances in the HIFU systems improved the capacities to scan, fuse MR images to target a specific zone, situation that improved the safety and possibility to ablate the cancer in a focalized location or a whole gland ablation, preserving continence and erections, with a proper selection of patients, with good results, comparable with surgery or radiation. In some post radiation failures, it is a very safe option to treat the recurrent cancer. In the case of BPH, the flexibility to ablate exclusively the prostate enlargement, preserving the urethra is a great advantage, considering a fast procedure, no bleeding, and a highly precise treatment, with improvement in the voiding function, improving IPSS and uroflowmetry parameters.
Part of the book: Advances in Soft Tissue Tumors
Molecular and Cell Biology of Cervical Cancer
The molecular and cell biology of cervical cancer will be covered in detail in this chapter, particularly emphasizing the disease’s etiology, brief epidemiology, risk factors, cervical cancer hallmarks, and the main signaling pathways involved. The chapter will go in-depth about the characteristics of cancer, such as changes in cell cycle regulation, apoptosis, and cell differentiation, as well as the tumoral microenvironment. Signal pathways like the PI3K/AKT/mTOR pathway and the Wnt/beta-catenin pathway will be highlighted for their significance in the development of cervical cancer. The chapter will thoroughly explain the molecular and cell biology underlying this terrible illness.
Part of the book: Cervical Cancer