Sumandeep Kaur

By Navdeep Singh Sidhu and Sumandeep Kaur

Acute pulmonary thromboembolism (PE) is a common disorder with significant mortality and morbidity. Timely recognition and prompt therapy of this disorder is essential to prevent adverse consequences. Thrombolytic therapy has an important role in the management of high-risk pulmonary embolism patients, where it can be lifesaving. However, the potential clinical benefit of thrombolytic therapy needs to balanced against the risk of major bleeding associated with the use of these agents. Hence patient selection is of paramount importance in determining the success of this therapy. Management strategies in PE are centered around the concept of risk stratification of the cases. In this chapter we briefly discuss the risk categorization of PE cases, followed by a more elaborative discussion of the role of thrombolytic therapy in the management of patients with high risk or intermediate risk PE.

Part of the book: New Knowledge about Pulmonary Thromoboembolism

By Navdeep Singh Sidhu and Sumandeep Kaur

Systemic hypertension is a major public health problem, nearly affecting one-third of the global adult population. It is the leading modifiable risk factor for coronary heart disease (CHD), cerebrovascular disease, renal dysfunction, peripheral arterial disease (PAD), heart failure and atrial fibrillation. Human brain is one of the most important target organs for hypertension related end-organ damage. Two major categories of hypertension related cerebral diseases include stroke and dementia, which are associated with considerable morbidity and mortality. Large body of clinical evidence has shown that adequate control of elevated blood pressures (BPs) could be a very effective tool in reducing the incidence and prevalence of cerebrovascular diseases. In the following sections, we discuss the role of hypertension in the causation of cerebrovascular disease along with the preventive and therapeutic strategies for the same.

Part of the book: Cerebrovascular Diseases