The aim this study is to describe the algorithms of kinetic modeling to analyze the pattern of deposition of amyloid plaques and glucose metabolism in Alzheimer’s dementia. A two-tissue reversible compartment model for Pittsburgh Compound-B ([11C]PIB) and a two-tissue irreversible compartment model for [18F]2-fluoro-2-deoxy-D-glucose ([18F]FDG) are solved applying the Laplace transform method in a system of two first-order differential equations. After calculating a convolution integral, the analytical solutions are completely described. In order to determine the parameters of the model, information on the tracer delivery is needed. A noninvasive reverse engineer technique is described to determine the input function from a reference region (carotids and cerebellum) in PET image processing, without arterial blood samples.
Part of the book: Recent Advances in Biomechanics