Gonzalo Gómez

My name is Gonzalo Ignacio Gómez Ordenes, Graduated in Biochemistry in 2011, Master\'s Degree in Biological Sciences in 2013, and PhD in Physiology in June 2017, whose name of my doctoral thesis was titled: \"The Via RhoA / ROCK regulates the activity of hemichannels and gap junctions formed by Cx43 in renal damage by Angiotensin II”. For 5 years (from 2011 to July 2016) I was working in the laboratory of Dr. Victoria Velarde and Dr. Juan Carlos Sáez, within the Department of Physiology, in the Faculty of Biological Sciences of the Pontificia Universidad Católica de Chile. I have learned various techniques, from primary culture to the ability to perform studies of functionality of Hemichannels and gap junctions formed by Connexins and Pannexins, at cellular and animal level, this focused mainly on understanding how hypertension can affect the function of the kidney. From August 2016 to February 2018, I work in the Neurosciences Laboratory at the Medical Research Center of the Pontificia Universidad Católica de Chile, under the responsibility of Dr. Juan Andrés Orellana, where I study the role of in vivo and in vitro treatment with ethanol in the production of pro-inflammatory and glial activation markers. My main scientific contributions in the last 5 years are the ones that I present below: • Gómez GI, Velarde V. Boldine Improves Kidney Damage in the Goldblatt 2K1C Model Avoiding the Increase in TGF-β. Int J Mol Sci. 2018 Jun 25;19(7). pii: E1864. doi: 10.3390/ijms19071864. • Gómez GI, Fernádez P, Velarde V, Sáez JC. Angiotensin II-Induced Mesangial Cell Damaged Is Preceded by Cell Membrane Permeabilization Due to Upregulation of Non-Selective Channels. Int J Mol Sci. 2018 Mar 23;19(4). pii: E957. doi: 10.3390/ijms19040957. • Gómez GI, Falcon RV, Maturana CJ, Labra VC, Salgado N, Rojas CA, Oyarzun JE, Cerpa W, Quintanilla RA, Orellana JA. Heavy Alcohol Exposure Activates Astroglial Hemichannels and Pannexons in the Hippocampus of Adolescent Rats: Effects on Neuroinflammation and Astrocyte Arborization. Front. Cell. Neurosci. 2018 Dec 12; 472. doi: 10.3389/fncel.2018.00472 • Sáez JC, Contreras-Duarte S, Gómez GI, Labra VC, Santibañez CA, Gajardo-Gómez R, Avendaño BC, Díaz EF, Montero TD, Velarde V, Orellana JA. Connexin 43 Hemichannel Activity Promoted by Pro-Inflammatory Cytokines and High Glucose Alters Endothelial Cell Function. Front Immunol. 2018 Aug 15;9:1899. doi: 10.3389/fimmu.2018.01899. eCollection 2018. • Labra VC, Santibáñez CA, Gajardo-Gómez R, Díaz EF, Gómez GI, Orellana JA. The Neuroglial Dialog Between Cannabinoids and Hemichannels. Front Mol Neurosci. 2018 Mar 20;11:79. doi: 10.3389/fnmol.2018.00079. eCollection 2018. • Gómez GI, Velarde V. Boldine treatment prevents kidney damage in rats with 5/6 Nephrectomy. IJMRPS, 3 (2): 80-90, 2016.